Less liver fat
- Published in
- Diabetes Care 2010
- People studied
- 96
In 96 people with type 2 diabetes, liver fat fell by 50.8% in a year in a lifestyle programme, against 22.8% in the comparison group.
- Checked against
- PubMed 20664019
- Published in
- Diabetes Care 2010
- Last checked
- 30 October 2026
Key takeaway
In 96 adults with type 2 diabetes and overweight or obesity from the Look AHEAD trial, liver fat was measured by scan before and after a year. People in the intensive lifestyle programme lost about 8.5% of their weight and their liver fat fell by 50.8%, against 22.8% in the support and education group. Fewer people in the programme developed a new fatty liver.
At a glance
- Type of study
- substudy of a randomised trial (Look AHEAD)
- People studied
- 96
- How long
- 12 months
- Compared with
- a diabetes support and education group
- Main result
- Liver fat fell by 50.8%, against 22.8% in the comparison group.
- Strength of evidence
- Small or uncontrolled studies
What this study does not show
This was a small substudy of 96 people, all with type 2 diabetes. Liver enzyme blood tests did not change clearly in a year.
Results from studies in groups of people, mostly in diet and movement programmes. They cannot be promised to any one person. This information is educational and does not replace a consultation with a doctor.
More on liver
- Less liver inflammationSmall or uncontrolled studies · Vilar-Gomez et al., Gastroenterology 2015
- Better liver biopsy resultsSmall or uncontrolled studies · Promrat et al., Hepatology 2010
- Less liver fatSmall or uncontrolled studies · Lazo et al., Diabetes Care 2010
- Remission of fatty liverRandomised trials · Wong et al., J Hepatol 2013
- Fatty liver can go awayLong-term or observational studies · Zelber-Sagi et al., J Hepatol 2012
- Less liver fat with exerciseRandomised trials · Katsagoni et al., Metabolism 2017
- Lower liver stiffness with dietLong-term or observational studies · Haigh et al., Clin Nutr 2022
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