Less liver inflammation
- Published in
- Gastroenterology 2015
- People studied
- 293
In a one-year study of 293 people with fatty-liver inflammation, it went away in 25% of everyone and in 90% of those who lost 10% or more. No comparison group.
- Checked against
- PubMed 25865049
- Published in
- Gastroenterology 2015
- Last checked
- 30 October 2026
Key takeaway
This study followed 293 people with fatty-liver inflammation (NASH), confirmed by a liver biopsy, a tiny sample of liver tissue. For a year they were encouraged to change their diet and activity, with a biopsy at the start and the end. Inflammation went away in 25% of everyone, and in 90% of those who lost 10% or more of their weight. The more weight people lost, the more the liver improved, but there was no comparison group.
At a glance
- Type of study
- study following people forward, with liver biopsies, no comparison group
- People studied
- 293
- How long
- 52 weeks
- Main result
- Liver inflammation went away in 25% overall and in 90% of those losing 10% or more.
- Strength of evidence
- Small or uncontrolled studies
What this study does not show
There was no comparison group, so the study cannot show how much of the change came from the programme itself. It was done at one centre in Cuba, and only 30% of people lost 5% or more.
Results from studies in groups of people, mostly in diet and movement programmes. They cannot be promised to any one person. This information is educational and does not replace a consultation with a doctor.
More on liver
- Less liver inflammationSmall or uncontrolled studies · Vilar-Gomez et al., Gastroenterology 2015
- Better liver biopsy resultsSmall or uncontrolled studies · Promrat et al., Hepatology 2010
- Less liver fatSmall or uncontrolled studies · Lazo et al., Diabetes Care 2010
- Remission of fatty liverRandomised trials · Wong et al., J Hepatol 2013
- Fatty liver can go awayLong-term or observational studies · Zelber-Sagi et al., J Hepatol 2012
- Less liver fat with exerciseRandomised trials · Katsagoni et al., Metabolism 2017
- Lower liver stiffness with dietLong-term or observational studies · Haigh et al., Clin Nutr 2022
The next step is a conversation, not a decision
A licensed doctor decides whether any treatment is right for you. The answer can also be no treatment.
1You fill in a short form
2We call you within 24 hours
3A paid 20-minute video consultation with a doctor
4The doctor goes through your options and decides what is right for you