Better heart risk factors

Published in: Diabetes Care 2011
People studied: 5,145

In 5,145 people with type 2 diabetes, losing 5 to 10% in a year went with better blood sugar, blood pressure and blood fats than keeping a stable weight.

Checked against: PubMed 21593294
Published in: Diabetes Care 2011
Last checked: 30 October 2026

Key takeaway

This analysis of the Look AHEAD trial followed 5,145 adults with type 2 diabetes and overweight or obesity for a year. Compared with people whose weight stayed stable, those who lost 5 to 10% had about 3.5 times the odds of a meaningful drop in HbA1c, a measure of long-term blood sugar. They also had better odds of improved blood pressure and blood fats (triglycerides and HDL, the 'good' cholesterol). Losing 10 to 15% went with even better odds for most of these.

At a glance

Type of study: observational analysis within a randomised trial (Look AHEAD)
People studied: 5,145
How long: 1 year
Compared with: people whose weight stayed stable
Main result: Losing 5 to 10% went with better blood sugar, blood pressure and blood fats.
Strength of evidence: Long-term or observational studies

What this study does not show

An observational analysis inside a trial, so it shows an association, not proof that the weight loss caused the changes. Everyone had type 2 diabetes, and LDL ('bad') cholesterol was not linked with weight loss.

Results from studies in groups of people, mostly in diet and movement programmes. They cannot be promised to any one person. This information is educational and does not replace a consultation with a doctor.